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PATTS - Nervous System

 

 
 
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Nervous System:

 CNS and PNS
 

 Contents:
 
Nerve Cells
The nervous system is the body's information gatherer, storage center and control system. Its overall functions are to collect information about the body's external/internal states and transfer this information to the brain (afferent system), to analyze this information, and to send impulses out (efferent system) to initiate appropriate motor responses to meet the body's needs. 

The system is composed of specialized cells, termed nerve cells or neurons, that communicate with each other and with other cells in the body.  A neuron has three parts:

  1. the cell body, containing the nucleus
  2. dendrites, hair-like structures surrounding the cell body, which conduct incoming signals.
  3. the axon (or nerve fiber), varying in length from a millimeter to a meter, which conduct outgoing signals emitted by the neuron. Axons are encased in a fat-like sheath, called myelin, which acts like an insulator and, along with the Nodes of Ranvier, speeds impulse transmission.
Typically a given neuron is connected to many thousands of neurons. The specific point of contact between the axon of one cell and a dendrite of another is called a synapse. Messages passed to and from the brain take the form of electrical impulses, or action potentials, produced by a chemical change that progresses along the axon. At the synapse, the impulse causes the release of neurotransmitters (like acetylcholine or dopamine) and this, in turn, drives the impulse to the next neuron. These impulses travel very fast along these chain of neurons -- up to 250 miles per hour. This contrasts with other systems,  such as the endocrine system, which may take many hours to respond with hormones.
Parts of a neuron Nerve cells
Myelinated Axon
The nerve cell bodies are generally located in groups. Within the brain and spinal cord, the collections of neurons are called nuclei and constitute the gray matter, so-called because of their color. Outside the brain and spinal cord the groups are called ganglia. The remaining areas of the nervous system are tracts of axons, the white matter, so-called because of white myelin sheath. Tracts carrying information of a specific type, such as pain or vision, generally have specific names. 

Somatosensory Receptors
Input (afferent system) to the nervous system is in the form of our five senses: touch/pain, vision, taste, smell, and hearing. Pain, temperature, and pressure are known as somatic senses. Sensory receptors are classified according to the type of energy they can detect and respond to. 

  • Mechanoreceptors: hearing and balance, stretching. 
  • Photoreceptors: light. 
  • Chemoreceptors: smell and taste mainly, as well as internal sensors in the digestive and circulatory systems. 
  • Thermoreceptors: changes in temperature. 
  • Electroreceptors: detect electrical currents in the surrounding environment. 
Major Divisions of the Nervous System
The nerves of the body are organized into two major systems: The two systems function together, with nerves from the periphery entering and becoming part of the central nervous system, and vice versa.
Nervous System Divisions
Peripheral Nervous System
  • In the PNS, collections of neurons are 
    called ganglia
    Central Nervous System
    • In the CNS, collections of neurons 
      are called nuclei

    Brain Structures
    The brain, the body's "control central," is one of the largest of adult organs, consisting of over 100 billion neurons and weighing about 3 pounds. It is typically divided into four parts:
    1. the cerebrum;
    2. the cerebellum;
    3. the diencephalon (thalamus, hypothalamus, sometimes classed as cerebral structures); and
    4. the brain stem (medulla oblongata, pons, midbrain), which is an extension of the spinal cord.
    Test yourselfTest yourself:
    Name the parts of the brain.
    Click on theseClick image for a primer on Parts of the Brain
    Graphics modified from: The InnerBody: Anatomy Tutorials - Nervous System

    Major Brain Structures


    Cerebrum
    The largest division of the brain, the cerebrum, consists of two sides, the right and left cerebral hemispheres, which are interconnected by the corpus callosum. The two hemispheres are "twins," each with centers for receiving sensory (afferent) information and for intiating motor (efferent) responses. The left side sends and receives information to/from the right side of the body, and vice versa. Various intellectual functions are concentrated in either the left or right hemispheres.

    The hemispheres are covered by a thin layer of gray matter known as the cerebral cortex. The interior portion consists of white matter, tracts, and nuclei (gray matter) where synapses occur. Each hemisphere of the cerebral cortex is divided into four "lobes" by various sulci and gyri: The sulci (or fissures) are the grooves and the gyri are the "bumps" on the brain's surface.
    brain - sensory/motor interaction
    Web resourcesWeb resources:
    The four lobes perform specific functions:

    1. frontal - controls fine movements (Betz cells)/ upper motor neuron) and smell. Also, center for abstract thinking, judgment, and language (left hemisphere)
    2. parietal - coordinates afferent infromation dealing with pain, temperature, form, shape, texture, pressure, and position. Some memory functions are also found here.
    3. temporal - handles dreams, memory, and emotions. Center for auditory function.
    4. occipital -  governs vision
    In addtion to the four lobes, you find basal ganglia. The basal ganglia, actually aggregates of neurons (gray matter), constitute the extrapyramidal system. The extrapyramidal system governs postural adjustment and gross voluntary movements, as opposed to fine movements, controlled by the frontal lobe.  The basal ganglia receive afferent input from the cerebral cortex and thalamus. Their axons synapse in the brain stem and the spinal cord.

    Function summary:

    • "Consciousness" - awareness of one's self and one's environment
    • Thought/ reasoning/ memory
    • Vision, hearing, touch
    • Speech, language
    • Motor control (fine and gross)/ coordination
    • Emotions ("limbic system" or the "emotional brain") 
    Cerebellum
    The cerebellum, the second largest brain structure, sits below the cerebrum. Like the cerebrum, the cerebellum has an outer cortex of gray matter and two hemispheres. It receives/relays information via the brain stem. The cerebellum performs 3 major functions, all of which have to do with skeletal-muscle control:

    Function summary:

    • Balance/ Equilibrium of the trunk (See also: Vestibular System)
    • Muscle tension, spinal nerve reflexes, posture and balance of the limbs
    • Fine motor control, eye movement. (Incoming information is transferred from the cerebral cortext via the pons. Outgoing information goes back to the cortex via the thalamus.) 
    Cerebellar disease (abscess, hemorrhage, tumors, trauma) results in ataxia (muscle incordination), tremors, and disturbances of gait and equilibrium. This can also interfere with a person's ability to talk, eat, and perform other self care tasks. Paralysis does not result from loss of cerebellar function. 

    Diencephalon
    The diencephalon, located between the cerebrum and the midbrain, consists of several important structures, two of which are the:

    • Thalamus: large, bilateral (right thalamus/left thalamus) egg-shaped mass of gray matter serving as the main synaptic relay center. Receives/relays sensory information to/from the cerebral cortex, including pain/pleasure centers.
    • Hypothalamus: a collection of ganglia located below the thalamus and intimatetly associated with the pituitary gland. It has a variety of functions: senses changes in body temperature; controls autonomic activites and hence regulates the sympathetic and parasympathetic nervous systems; links to the endocrine system/controls the pituitary gland; regulates appetite; functions as part of the arousal or alerting mechanism; and links the mind (emotions) to the body -- sometimes, unfortunately, to the degree of producing "psychosomatic disease."
    Function summary:
    • Voluntary movement/ motor integration
    • Perception/ Sensory/mind-body integration
    • Temperature
    • Appetite
    Brain Stem
    The medulla oblongata, pons, and midbrain (mesencephalon or cerebral peduncles) -- often referred to collectively as the brain stem -- control the most basic life functions. Of these three, the medulla is the most important. In fact, so vital is the medulla to survival that diseases or injuries affecting it often prove fatal. All functions of the brain stem are associated with cranial nerves III-XII.

    Function summary:

    • Breathing/respiration (pons, medulla)
    • Heart rate/ action (medulla)
    • Blood pressure (vasoconstriction)/ blood vessel diameter (medulla)
    • Reflex centers for pupillary reflexes and eye movements (midbrain, pons); and for vomiting, coughing, sneezing, swallowing, and hiccuping (medulla).
    Blood supply
    An intricate arterial structure supplies the brain with oxygen-rich blood. At the brain stem, two vertebral arteries, entering through the first cervical vertebrae,  join to form the basilar artery. The basilar artery along with two internal carotid arteries, entering through holes at the base of the skull, interconnect at the Circle of Willis. From there, the anterior and middle cerebral arteries arise; the posterior cerebral artery arises from the basilar system. 

    Cranial Nerves
    There are 12 pairs of cranial nerves. Some bring information from the sense organs to the brain; some control muscles; others are connected to glands or internal organs. 
    Cranial nerves - bootm view of brain
    The nerves are often remembered by the
    mnemonic ...

    "On Old Olympic Towering Top 
    A Famous Vocal German 
    Viewed Some Hops"

    ... standing for: Ofactory, Optic, Oculomotor, Trochlear, Trigeminal, Abducens, Facial, Vestibulocochlear, Glossopharyngeal, Vagus, Spinal accessory, Hypoglossal. 
     

    Web resourceInteractive Review
    Cranial Nerve Major Functions
    I Olfactory smell
    II Optic vision 
    III Oculomotor eyelid and eyeball movement
    IV Trochlear innervates superior oblique
    turns eye downward and laterally 
    V Trigeminal chewing 
    face & mouth touch & pain
    VI Abducens turns eye laterally 
    VII Facial controls most facial expressions 
    secretion of tears & saliva
    taste 
    VIII Vestibulocochlear
    (auditory) 
    hearing 
    equillibrium sensation 
    IX Glossopharyngeal taste 
    senses carotid blood pressure 
    X Vagus senses aortic blood pressure 
    slows heart rate 
    stimulates digestive organs
    taste 
    XI Spinal Accessory controls trapezius & sternocleidomastoid
    controls swallowing movements
    XII Hypoglossal controls tongue movements 
    Test yourself Test yourself: Think you can identify the location and function of all the cranial nerves?  Try these two interactive quizzes.
         1. Cranial nerve locations
         2. Cranial nerve functions
    Spinal Cord
    Web resourceMotions and Functions Available at Different Levels of Spinal Cord Injury
    Vertebral columnThe spinal cord lies within the spinal cavity, consisting of the vertebral column, the meninges, spinal nerves, spinal fluid, blood vessels, and a cushion of adipose/fat tissue. The spinal cord has two general functions: 1) It provides the two-way conduction routes to/from (afferent/efferent) the brain; and 2) it serves as the reflex center for all spinal reflexes. Thirty-one pairs of nerves connect to the spinal cord. They have no special names, but are numbered according to the level of the spinal column from which they emerge. There are 8 cervical (C1-C8), 12 thoracic (T1-T12), 5 lumbar (L1-L5), 5 sacral (S1-S5), and 1 coccygeal pairs of spinal nerves. 

    Spinal cord
    The figure below shows a cross-section of the spinal cord at a typical level, illustrating the position of the horns, where the nerves synapse, and the three main tracts:
    1. Spinothalamic tract, carrying pain and temperature impulses to the thalamus and the parietal lobe
    2. Posterior columns, carrying position and pressure sense to the thalamus and the parietal lobe
    3. Corticospinal (or pyrimidal) tract, carrying impulses to initiate muscle activity from the frontal lobe.
    cross section of spinal cordDorsal root ganglion
    Each nerve has two roots connecting to the spinal cord: The posterior (dorsal) is the sensory root; the  anterior (ventral) is the motor root. Sensory receptors send information to the spinal cord (and thus to the brain) through the spinal nerve. The cell bodies for these nerve fibers are located in the dorsal root ganglion and enter the spinal cord through the dorsal/posterior root. Some fibers synapse with other neurons in the dorsal/posterior horn, while others continue up to the brain. The cell bodies in the ventral/anterior horn send axons through the ventral/anterior root to muscles to control movement. 

    Reflexes
    A reflex is an automatic, i.e."involuntary," response of the body to some stimulus, e.g. pupil dilation, to collect more light, at night. Reflexes have afferent (signals to the CNS) and efferent (signals from the CNS) components and may involve one nerve/synapse (monosynaptic reflex) or multiple synapses (polysynaptic reflex).  The simplest spinal reflex is the tendon reflex, a monosynaptic reflex. When the tendon is tapped, the sensory receptor in the muscle sends a signal to the spinal cord (afferent system), where it enters through the dorsal/posterior root, then synapses with a sensory nerve axon in the ventral/anterior horn. From there, the receiving axon carries the impulse through the ventral/anterior root back to the muscle (efferent system) whose tendon was tapped. The muscle jerks/ contracts.

    Spinal/Peripheral Nerves
    All cervial spinal nerves control movement of the shoulder and arm muscles and receive all sensory input from the skin, muscles, bones, and joints. After leaving the vertebral canal, they merge to form peripheral nerves. The merger of the spinal nerves in the neck region is called the brachial plexis
     

    Main Action of the Brachial Plexus Nerves
    Modified from: Joel DeLisa and Walter C. Stolov, "Significant Body Systems," in: Handbook of Severe Disability, edited by Walter C. Stolov and Michael R. Clowers. US Department of Education, Rehabilitation Services Administration, 1981, p. 27.
    Peripheral Nerve Action
    Axillary Flex and abduct shoulder
    Musculocutaneous Flex elbow
    Radial Extend elbow, wrist, and fingers
    Median Flex wrist and fingers
    Ulnar Dexterity of fingers

    The thoracic spinal nerves do not recombine into plexuses. The anterior roots control the muscles of the abdomen and back; the posterior roots receive information from the abdomen, skin, and muscles and joints of the chest and upper back. The lumbar and sacral nerves, like the cervical, do combine after leaving the vertebral canal. This merger, occuring in the pelvis, is called the lumbosacral plexus, which controls the movement of, and receives information from, the lower extremities, bladder, and bowel.
     

    Main Action of the Lumbosacral Plexus Nerves
    Modified from: Joel DeLisa and Walter C. Stolov, "Significant Body Systems," in: Handbook of Severe Disability, edited by Walter C. Stolov and Michael R. Clowers. US Department of Education, 
    Rehabilitation Services Administration, 1981, p. 28.
    Peripheral Nerve Action
    Femoral Extend knee
    Sciatic Flex knee
    Tibial Flex ankle and toes
    Peroneal Extend ankle and toes
    Pudendal Anal and urethral sphincters and erection